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Why do we get wrinkles?

As we get older, cell regeneration happens more slowly and the skin becomes thinner and more fragile. The appearance of wrinkles is not only caused by ageing, but also by a decrease in the elasticity and hydration of the skin. In fact, even young people have wrinkles: wrinkles are formed where the most important muscular movements occur, which require special elasticity in the skin.

When our cellular metabolism slows down, the skin undergoes a profound change, and the skin on the face starts to sag, lose its elasticity and deep wrinkles may form. The first wrinkles to appear are the expression lines, caused by the facial contractions that, when repeated, are imprinted on the underlying dermis that simultaneously loses its tone. With the loss and alteration of collagen and elastic fibres, the tissues begin to relax, the skin loses its support and the oval of the face begins to deform. The lack of collagen manifests itself in the lack of tonicity, loss of elasticity and hydration and therefore in the appearance of wrinkles.

What is collagen?

It is the most abundant structural protein in the human body, representing 25% of the total weight. It is synthesised by our body and provides elasticity and resistance for our organs and tissues. It constitutes 75% of our skin and a lack of collagen will manifest itself in a lack of tonicity, loss of elasticity and in the appearance of wrinkles.

How many types of collagen exist in our body?

Mammals have about 30 types of collagen chains. Type I collagen makes up for 90% of the total collagen in our bodies and enters the composition of the main connective tissues, such as skin, tendons, bones and cornea.

Is collagen also useful for joints?

In our body there are many types of collagen (over 30): type I collagen is mainly present in the skin, type II collagen, on the other hand, is present in the joints. The collagen contained in Biocollagenix is type I collagen and is therefore aimed at our well-being and skin care.

But if collagen is a protein, can I use any protein supplement to improve my skin?

Collagen has a very characteristic composition in amino acids: about a third of its residues are glycine; another 15-30% consists of proline and 4-hydroxyproline. These amino acids are found in minimal quantities in food and protein supplements aimed at other applications. So, to restore the collagen in the skin, we have to use a source of collagen, like Biocollagenix.

For whom has Biocollagenix been studied?

The formulation of Biocollagenix has been developed by ESI’s research laboratories taking into consideration all the people who want to take care of their skin, with a stimulating action from inside the body. Ideal in cases of excessive sun exposure, for people working indoors and in air-conditioned rooms that dehydrate the skin.

Where can I buy Biocollagenix?

Like all ESI products, Biocollagenix can be purchased in pharmacies, parapharmacies and herbalists.

Where is Biocollagenix produced?

Biocollagenix is produced in Italy by ESI Spa, a company that for over 40 years has been operating at the highest levels in the field of food supplements, nutraceuticals, natural cosmetics and medical devices. ESI was one of the first companies in the sector to achieve ISO 9001 certification, back in 1999. Today, ESI products are distributed in over 50 countries.

What tests does Biocollagenix undergo to ensure quality and safety?

The ESI production standards are at the highest quality levels and are the result of state-of-the-art production facilities and state-of-the-art research, development and quality controls. The stringent controls run by ESI on the raw materials: the Quality Control Laboratory is directly involved in organoleptic tests, physical-chemical and microbiological analyses of the best raw materials. Each batch of raw material is analysed before being used, as well as during and at the end of the production.

Why use Biocollagenix instead of anti-ageing creams?

The skin is formed by 2 superimposed layers, the dermis (deeper layer) and the epidermis (superficial layer). The dermis is the deepest layer of the skin. It consists of connective tissue, rich in collagen fibres which give elasticity and resistance to the skin. In contrast, the epidermis is made up of cells called keratinocytes, arranged over 5 layers, which correspond to the same cells at different times in their life cycle. The epidermis is continually renewed through a process of proliferation and differentiation that leads new cells, generated in the deepest layer, to migrate and transform themselves through the overlying layers, until they are dispersed by desquamation. The last layer is in fact made up of dead keratinocytes. The application of a cream on the epidermis does not succeed in conveying the nourishing principles into the innermost layers of the dermis. Instead, the nourishment arrives via the bloodstream into the cells of the deeper layers, as the cells are pushed outwards they die and fall apart. This is why the right nourishment of the skin must be provided via the bloodstream, and therefore via the diet, and not only externally by using cosmetic products.

For how long do you need to use Biocollagenix before you can see the first results?

As with all other products for external and internal use, whether they are natural or pharmaceutical, effectiveness may vary significantly from one individual to another. In this case, results will depend on the type of skin, the life style, diet, and general health. For example, excessive exposure to UV rays will extend the time required to obtain the desired results. A first improvement of the skin parameters can be obtained with a couple of packs, so in about 20 days. When continuing the treatment, the skin may appear smoother and firmer after a month. We recommend an initial treatment period of 1-2 months, after which the consumer may decide to continue or to alternate between one-month treatment periods and suspending treatment.

Where is Biocollagenix collagen extracted from?

ESI Spa uses hydrolysed marine collagen extracted from the skin of fish; no other animals are used, such as pigs, cattle or poultry. The fish used comes from farms that are strictly controlled and guaranteed for human consumption.

Is my skin’s collagen the same as the collagen in Biocollagenix?

The collagen in our body is a very large protein, made up of many amino acids bound together. It is so large that, when applied to the skin or ingested, it would not be absorbed by the body. Therefore, the collagen used in Biocollagenix is hydrolysed, i.e. fragmented into smaller molecules (peptides containing amino acids needed to activate collagen synthesis): easily digested, assimilated and transported to the deeper layers of the skin where the synthesis of the new collagen will be activated.

What is hyaluronic acid and how does it work on the skin?

Hyaluronic acid is one of the main constituents of connective tissue. With age, its concentration in the skin is reduced and as a result wrinkles will form.

What is the origin of hyaluronic acid?

The hyaluronic acid used in Biocollagenix, in the form of sodium hyaluronate, is obtained through a natural process of bacterial fermentation.

What is resveratrol?

Resveratrol is a molecule of plant origin, often extracted from grape skins: it is linked to the beneficial effects of red wine.

Why does Biocollagenix contain antioxidant principles?

Cellular oxidation is one of the main causes of skin ageing: it causes the formation of free radicals and participates in the degeneration of skin cells. The process of cellular oxidation is generated by various external factors, such as stress, UV rays and pollution. The process is characterised by the destabilisation of a molecule due to the loss of an electron. The result is a cascade reaction that can have different consequences: the metabolism of skin cells is altered and the epidermis regenerates badly and less quickly. For this reason, Biocollagenix contains blueberries, vitamin C, zinc and copper, which have an antioxidant action and protect cells from oxidative stress.

Is vitamin C useful for the skin?

In addition to the many activities it performs in our body, vitamin C also contributes to the formation of collagen for normal skin function. Thanks to its antioxidant properties, it contributes to the protection of cells from oxidative stress.

What is the function of copper and zinc?

Copper contributes to the maintenance of normal connective tissues and zinc contributes to the maintenance of normal skin.

Can gastric juices deactivate collagen and the other components of Biocollagenix making them ineffective?

The formulation is designed to maintain the characteristics of the ingredients, and the collagen peptides maintain their structure to be rapidly absorbed in the intestine and transported into the dermis. In this regard, several studies have shown that some of the peptides present in hydrolysed collagen, in particular those containing hydroxyproline, are able to cross the intestinal barrier and the proline-hydroxyproline peptide is the most abundant peptide in plasma.

Can I take Biocollagenix together with other food supplements?

Interactions with other supplements are not known. It is however important to consider the quantities of vitamins and minerals contained in the various supplements and avoid exceeding the daily nutritional needs; the DRV, Dietary Reference Values are indicated on the packages. In case of doubt about the interpretation, it is advisable to consult a doctor or a healthcare professional.

Can Biocollagenix be taken with other medication?

There have never been any interactions with other medication due to the components of Biocollagenix. However, it is advised, for those suffering from particular pathologies and undergoing pharmacological treatment, to consult their doctor before taking the product.

What does the product taste like?

Biocollagenix is guava flavoured, a typical fruit of Central America, with an extremely fragrant flavour and a strong and attractive fragrance.

Can taking Biocollagenix long-term increase my body weight?

Certainly not. Biocollagenix contains sugars and fats amounting to less than 0.5%, so it can be declared sugar-free and fat-free. Therefore it cannot contribute to an increase in body weight.

Can it be used during pregnancy and lactation?

At present, no clinical studies have been performed on pregnant and lactating women, so it is not possible to suggest use in these particular cases.

Can it be used during the menopause?

Its use during menopause is not advised. In case of pharmacological treatment, it is advised to consult a doctor.

Is Biocollagenix suitable for diabetics?

Our product contains stevia, a natural zero-calorie sweetener. Furthermore, the product contains less than 0.5% of sugar, therefore it can be declared sugar-free.

What are the side effects of Biocollagenix?

Biocollagenix contains collagen from fish and also soy lecithin. Therefore the product is not recommended for people allergic to these foods. No other side effects are known.

Does Biocollagenix contain gluten?

No, like all ESI supplements, Biocollagenix is gluten-free.

Could Biocollagenix contain traces of GMOs, antibiotics, hormones, artificial colours or flavours or substances obtained through nanotechnologies?

No, it does not contain any of these elements.

Is Biocollagenix suitable for vegetarians and/or vegans?

Biocollagenix contains collagen extracted from fish skin.

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